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51st ERA-EDTA CONGRESS

 

31 May - 3 June 2014 AMSTERDAM
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Discussion forum - 51st ERA-EDTA CONGRESS
    Topic - N) Renal Transplantation. N1) Transplantation basic science and immune-tolerance of allogenic and xenogenic transplants.

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Poster: 632
Visits: 31
Title: 123I-MIBG SCINTIGRAPHY SUGGESTS FUNCTIONAL SYMPATHETIC REINNERVATION IN HUMAN KIDNEY ALLOGRAFTS
Authors: Linn Dobrowolski , Hein J. Verberne, Frederike J. Bemelman, Ineke J.M. ten Berge and C.T. Paul Krediet
Centre: Academic Medical Center at the Universtity of Amsterdam

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123I-MIBG SCINTIGRAPHY SUGGESTS FUNCTIONAL SYMPATHETIC REINNERVATION IN HUMAN KIDNEY ALLOGRAFTS

Linn Dobrowolski
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Subspeciality
Reg: 5/20/2014 1:59:00 PM
Comment# 1
Sympathetic denervation might be involved in the pathogenesis of allograft nephropathy. At time of transplantation the allograft is entirely denervated, but histological evidence suggests reinnervation after transplantation. However, the functional significance of this reinnervation is unknown. Assessment of functional sympathetic nerves in human organs is possible with 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy. MIBG is a noradrenaline analogue that accumulates in adrenergic tissue. When labelled with 123Iodine, MIBG can be visualized. Cardiac 123I-MIBG imaging is routinely used for the measurement of cardiac sympathetic activity in chronic heart failure patients. Uptake reflects the density/intactness of the neural tissue within the organ. Wash-out rate is thought to reflect sympathetic activity. Hypothesis: human renal allograft sympathetic reinnervation - as visualized by 123I-MIBG uptake - is a slow process that takes &8805; 10 years to reach functional capacity.

Comment added on 5/20/2014 1:59:00 PM 
     
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Most viewed poster for this congress
Poster: 7
Visits: 477
Title: SEVERE SYMPTOMATIC ACUTE HYPONATREMIA IN TRAUMATIC BRAIN INJURY RESPONDS VERY RAPIDLY SINGLE 15 MG DOSE OF TOLVAPTAN: A MAYO CLINIC HEALTH SYSTEM HOSPITAL EXPERIENCE - NEED FOR CAUTION WITH TOLVAPTAN IN YOUNGER PATIENTS WITH PRESERVED RENAL FUNCTION
Authors: MACAULAY ONUIGBO ,
Centre: MAYO CLINIC, ROCHESTER & MAYO CLINIC HEALTH SYSTEM, EAU CLAIRE

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Poster: 645
Visits: 106
Title: LONG-TERM KIDNEY ALLOGRAFT SURVIVAL IN PATIENTS WITH TRANSPLANT GLOMERULITIS
Authors: Maria Khrabrova ,
Centre: Pavlov First Saint-Petersburg State Medical University; Nephrology Center of Lower Saxony


 








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